Bacteriocidal Action of Hydroxyurea onEscherichia coliK12recA
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چکیده
منابع مشابه
Reactive oxygen species are partially involved in the bacteriocidal action of hypochlorous acid.
Hypochlorous acid (HOCl) is probably the most widely used disinfectant worldwide and has an important role in inflammatory reaction and in human resistance to infection. However, the nature and mechanisms of its bactericidal activity are still poorly understood. Bacteria challenged aerobically with HOCl concentrations ranging from 9.5 to 76 microM exhibit higher ability to form colonies anaerob...
متن کاملFurther studies on the mechanism of action of hydroxyurea.
Addition of the four deoxyribonucleosides in vitro to 6C3HED mouse ascites tumor stimulates 32P incorporation into DNA and depresses incorporation into RNA at concentrations greater than 10~4 M. The four ribonucleosides stimulate incorporation into both DNA and RNA. Hydroxyurea blocks the ribonucleoside stimulation of 32P incorporation into DNA but not RNA. The inhibition of 32P incorporation i...
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The sensitivity of bacteria to the marine neurotoxins, brevetoxins, produced by the dinoflagellate Karenia brevis and raphidophytes Chattonella spp. remains an open question. We investigated the bacteriocidal effects of brevetoxin (PbTx-2) on the abundance and community composition of natural microbial communities by adding it to microbes from three coastal marine locations that have varying de...
متن کاملAction of hydroxyurea on the nucleic acid metabolism and viability of HeLa cells.
of 16 hr produced a loss of cell viability accompanied by an inhibition of DNA synthesis. Continued synthesis of RNA and protein suggests an unbalanced growth similar to that previously observed with 5-fluorodeoxyuridine, excess thymidine, and 1-/8D-arabinofuranosylcytosine. A threefold increase in thymidine kinase activity was observed as a result of unbalanced growth following the exposure of...
متن کاملHydroxyurea Analogues of Fosmidomycin
Z. Naturforsch. 58b, 106 – 110 (2003); received September 18, 2002 Benzyloxyureas (4) have been prepared by reactions of diethyl 3-benzyloxyamino-propyl-phosphonate (3) with isocyanates, potassium cyanate or 1,1’-carbonyldiimidazole / methylamine. Conversion of phosphonic esters 4 into phosphonic acids 6 by means of bromotrimethylsilane and catalytic hydrogenation of 4, 6 afforded the target co...
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ژورنال
عنوان ژورنال: Japanese Journal of Microbiology
سال: 1975
ISSN: 0021-5139
DOI: 10.1111/j.1348-0421.1975.tb00850.x